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Sunday, July 26, 2020 | History

4 edition of B cells and autoantibody production in autoimmune diseases found in the catalog.

B cells and autoantibody production in autoimmune diseases

by Christian Boitard

  • 33 Want to read
  • 30 Currently reading

Published by Chapman & Hall, R.G. Landes Co. in New York, Austin .
Written in English

    Subjects:
  • Autoimmunity.,
  • Autoantibodies.,
  • B cells.,
  • Autoimmune diseases.,
  • Autoantibodies.,
  • Autoimmune Diseases -- etiology.,
  • B-Lymphocytes -- immunology.

  • Edition Notes

    Includes bibliographical references and index.

    StatementChristian Boitard.
    SeriesMedical intelligence unit, Medical intelligence unit (Unnumbered)
    Classifications
    LC ClassificationsQR188.3 .B65 1996
    The Physical Object
    Pagination273 p. :
    Number of Pages273
    ID Numbers
    Open LibraryOL790403M
    ISBN 100412101718
    LC Control Number95022862

      In systemic lupus erythematosus (SLE), and perhaps other autoantibody-mediated diseases, oestrogen seems to increase the risk of disease in genetically predisposed women by targeting key immune Cited by: The immune system’s ability to distinguish self from nonself is essential for initiating host defense against microbial antigens and protection of self-antigens from autoimmune-associated destruction. Virus infections have been implicated in the initiation of multiple human autoimmune diseases. This chapter aims to summarize the main principles for some specific viral Author: Subuhi Sherwani, Mushtaq Ahmed Khan, Mohammed SulimanAlmogbel.

      Autoantibody-secreting B cells and memory B cells that continuously generate autoantibodies are also created, setting the body up for ongoing attacks, chronic inflammation and -- over time.   One common feature of autoimmune diseases like systemic lupus erythematosus (SLE) is the presence of high titers of self-reactive antibodies. These result in immune complexes, inflammation, and tissue pathology. Consequently, the checkpoints that normally keep immunoglobulin G (IgG)–positive autoreactive B cells in check are of intense Cited by: 9.

    The cell types that would be present in a B cell clone include B-Memory Cells, which are responsible for immunological memory, and plasma cells which are antibody producing 'factories'. Describe the specific roles of helper, cytotoxic and regulatory T cells in cell-mediated immunity.   The immune mechanisms implicated in the development of autoimmune diseases have been categorized into two broad sets of diseases: one set in which the pathological process is driven mainly by T cells and the other in which the humoral B response mainly mediates the disorder by producing autoantibodies that are able to bind tissue self Cited by:


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B cells and autoantibody production in autoimmune diseases by Christian Boitard Download PDF EPUB FB2

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled. The B1 B-cell equivalent subset and its role in human autoimmune diseases, however, remain to be delineated.

Although there is an increase in CD5 + B cells in both SLE and pSS, these cells may represent an expended population of pre-naïve conventional B2 cells and not the human equivalent of B1 cells [6].Cited by:   Having been considered for a long time as a T cell-dominated disease, based on the T cell-driven animal model of experimental autoimmune encephalomyelitis (EAE), B cells have moved into focus over the recent years, inspired by the success of B cell-directed therapies [1,9,10] and emerging experimental evidence of direct B cell involvement extending far beyond their role as mere antibody-producing cells Cited by: Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell.

The use of monoclonal antibodies that specifically target B cells, in particular anti-CD20 and ant-BLyS antibodies, have demonstrated the efficacy of this approach for the treatment of human autoimmunity, but questions remain open, how these B cell-targeted therapies work and why in certain autoimmune diseases clinical benefit is unpredictably : Thomas H.

Winkler, Reinhard E. Voll. Development of high-affinity antibodies requires cognate B cell/T cell interactions to initiate and sustain the GC. Somatically mutated autoantibodies in autoimmune disease are thought to be derived through T cell–dependent pathways, especially because the presence of autoantibodies is often correlated with the presence of specific HLA alleles (20, 21).

(B) Activated CD4 T cells play a central role in inflammatory responses in the synovial membrane, including autoantibody production by plasma cells, secretion of inflammatory cytokines by macrophages and synoviocytes, bone erosion by osteoclasts and inhibition of collagen secretion by : Patricia Castro-Sánchez, Pedro Roda-Navarro.

Immune complexes are often associated with systemic autoimmune disease. Autoreactive B and T cells persist in normal subjects but in disease are selected by autoantigen in the production of autoimmune responses.

Microbial cross-reaching antigens and cytokine dysregulation can lead to Size: 1MB. “Islet autoantibody” is a generic term for any one of a group of autoantibodies that are directed against the islets of Langerhans or, in some circumstances, are directed specifically against autoantigens of the insulin-secreting β cells.

β-Cell death that causes type 1A diabetes (T1DM) 3 seems to result from a cell-mediated autoimmune process initiated by yet Cited by: The loss of immune tolerance, increased antigenic load, excess T cell help, defective B cell suppression, and shifting of T helper 1 (Th1) to Th2 immune responses lead to B cell hyperactivity and the production of pathogenic autoantibodies.

10 Autoantibodies and Systemic Autoimmune Diseases (Karsten Conrad and Michael Bachmann). Characteristics and Classification of Systemic Autoimmune Diseases.

Distinguishing Features of Systemic Autoimmune Disease-Specific Autoantibodies. Autoantibodies as Diagnostic and/or Prognostic Markers in Systemic Autoimmune Diseases. The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal by: Publisher Summary.

This chapter describes experimental autoimmune uveoretinitis (EAU) in the rat and the mouse. EAU is a prototypic T-cell-mediated autoimmune disease that targets the neural retina and related tissues. A unique advantage of the EAU model is that it permits direct visual inspection of disease development and progression.

Since publication of the 4th Edition of The Autoimmune Diseases inthe understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune Book Edition: 5.

This has only been examined in mice so far, but the researchers now want to use the confetti model to look at how B cell production of autoantibodies is regulated and gets sped up.

Eventually, blocking the germinal centres in some way could put a break in the vicious cycle that autoimmune diseases create.

There is, therefore, a growing body of thought to suggest that disrupted B cell activation and/or autoantibody production/clearance could be playing a key role in most autoimmune diseases and that greater understanding of these pathways could be. The dysfunction may be due to problems in antibody production, impaired cell-mediated immunity, a combined type of antibody/cellular deficiency, impaired phagocytosis, or complement deficiency.

Immune system disorders may result in recurrent and unusual infections, or inflammation and dysfunction of the body's own tissues. The second proposes that autoantibody production results from a generalized process of antigen-independent polyclonal B cell activation 3,4.

Several years ago, we suggested a synthesis of these ideas: that polyclonal activation initiated autoantibody production while autoantigenic stimulation perpetuated the process by: 6.

Additional Physical Format: Online version: Boitard, Christian, B cells and autoantibody production in autoimmune diseases. New York: Chapman & Hall ; Austin. Among these B cell subsets self-reactive B cell clones are frequently detected, and may well contribute to autoantibody production and autoimmune disease [ ].

Recent evidence, however, also implicates a role for ‘conventional’ B2 cells in .B Cells Producing Pathogenic Autoantibodies. the role of B cells in autoimmune disease was thought to be predominantly limited to the production of autoantibodies. Abnormalities in B-cell. However, when introduced into mouse strains other than MRL, the mutated Fas gene did not result in significant autoantibody production associated with florid autoimmune disease.

B cells responsible for autoantibody production also occur in autoimmune disease-prone strains not mutated at Fas/FasL; in fact, the majority of autoimmune diseases in Cited by: